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- Title
NOX enzymes and Toll-like receptor signaling.
- Authors
Ogier-Denis, Eric; Mkaddem, Sanae; Vandewalle, Alain
- Abstract
Invading microorganisms are recognized by the host innate immune system through pattern recognition receptors. Among these receptors, Toll-like receptors (TLRs) are able to sense the molecular signatures of microbial pathogens, protozoa, fungi, and virus and activate proinflammatory signaling cascades. In addition to their role in bacterial killing by phagocytes, reactive oxygen species generated by NADPH oxidase (NOX) homologues also play key roles in signaling and host defense in a variety of cell types. Recent studies have demonstrated a link between TLR activation and NOX homologues following microbial recognition highlighting their important role in the innate immune response and host defense.
- Subjects
ENZYMES; NAD (Coenzyme); OXIDASES; REACTIVE oxygen species; DETECTION of microorganisms
- Publication
Seminars in Immunopathology, 2008, Vol 30, Issue 3, p291
- ISSN
1863-2297
- Publication type
Article
- DOI
10.1007/s00281-008-0120-9