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- Title
Neuronal lineages derived from the nerve-associated Schwann cell precursors.
- Authors
Kameneva, Polina; Kastriti, Maria Eleni; Adameyko, Igor
- Abstract
For a long time, neurogenic placodes and migratory neural crest cells were considered the immediate sources building neurons of peripheral nervous system. Recently, a number of discoveries revealed the existence of another progenitor type—a nerve-associated multipotent Schwann cell precursors (SCPs) building enteric and parasympathetic neurons as well as neuroendocrine chromaffin cells. SCPs are neural crest-derived and are similar to the crest cells by their markers and differentiation potential. Such similarities, but also considerable differences, raise many questions pertaining to the medical side, fundamental developmental biology and evolution. Here, we discuss the genesis of Schwann cell precursors, their role in building peripheral neural structures and ponder on their role in the origin in congenial diseases associated with peripheral nervous systems.
- Subjects
SCHWANN cells; PERIPHERAL nervous system; EVOLUTIONARY developmental biology; CHROMAFFIN cells; NEURAL crest; DEVELOPMENTAL biology; NEURAL stem cells; SUBMUCOUS plexus
- Publication
Cellular & Molecular Life Sciences, 2021, Vol 78, Issue 2, p513
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-020-03609-5