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- Title
Crosstalk between Statins and Cancer Prevention and Therapy: An Update.
- Authors
Grabarek, Beniamin Oskar; Boroń, Dariusz; Morawiec, Emilia; Michalski, Piotr; Palazzo-Michalska, Veronica; Pach, Łukasz; Dziuk, Barbara; Świder, Magdalena; Zmarzły, Nikola
- Abstract
The importance of statins in cancer has been discussed in many studies. They are known for their anticancer properties against solid tumors of the liver or lung, as well as diffuse cancers, such as multiple myeloma or leukemia. Currently, the most commonly used statins are simvastatin, rosuvastatin and atorvastatin. The anti-tumor activity of statins is largely related to their ability to induce apoptosis by targeting cancer cells with high selectivity. Statins are also involved in the regulation of the histone acetylation level, the disturbance of which can lead to abnormal activity of genes involved in the regulation of proliferation, differentiation and apoptosis. As a result, tumor growth and its invasion may be promoted, which is associated with a poor prognosis. High levels of histone deacetylases are observed in many cancers; therefore, one of the therapeutic strategies is to use their inhibitors. Combining statins with histone deacetylase inhibitors can induce a synergistic anticancer effect.
- Subjects
CANCER prevention; HISTONE deacetylase inhibitors; CANCER treatment; STATINS (Cardiovascular agents); HISTONE acetylation; CANCER cells
- Publication
Pharmaceuticals (14248247), 2021, Vol 14, Issue 12, p1220
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph14121220