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- Title
Tumor Immunotherapy Using A2A Adenosine Receptor Antagonists.
- Authors
Zhang, Jinfeng; Yan, Wenzhong; Duan, Wenwen; Wüthrich, Kurt; Cheng, Jianjun
- Abstract
The A2A adenosine receptor (A2AAR) plays critical roles in human physiology and pathophysiology, which makes it an important drug target. Previous drug-discovery efforts targeting the A2AAR have been focused on the use of A2AAR antagonists for the treatment of Parkinson's disease. More recently, the A2AAR has attracted additional attention for its roles in immuno-oncology, and a number of A2AAR antagonists are currently used as lead compounds for antitumor drugs in both preclinical models and clinical trials. This review surveys recent advances in the development of A2AAR antagonists for cancer immunotherapy. The therapeutic potential of representative A2AAR antagonists is discussed based on both animal efficacy studies and clinical data.
- Subjects
ADENOSINES; PARKINSON'S disease; IMMUNOTHERAPY; ANIMAL models in research; HUMAN physiology; ANTINEOPLASTIC agents; PURINERGIC receptors
- Publication
Pharmaceuticals (14248247), 2020, Vol 13, Issue 9, p237
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph13090237