We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Use of venetoclax in t(11;14) positive relapsed/refractory multiple myeloma: A systematic review.
- Authors
Khan, Wardah Javed; Ali, Mubeen; Hashim, Sana; Nawaz, Huma; Hashim, Syeda Nafeesa; Safi, Danish; Inayat, Arslan
- Abstract
Background: The plasma cell malignancy, multiple myeloma (MM), remains incurable despite advanced treatment protocols. Overexpression of Bcl-2 (an anti-apoptotic protein), in MM harboring the translocation (11;14), contributes to resistance to prior therapy. Venetoclax, a selective oral inhibitor of BCL-2 is a novel agent that shows promise as a therapeutic agent. Aims: The objective of this systematic review is to address how the use of venetoclax, alone or as a combination regimen, contributed to the treatment of patients with t(11:14) positive relapsed/refractory multiple myeloma (RRMM). Data sources: This systematic review was conducted in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was done on 5th June 2022. A literature search was conducted on PubMed and Scopus, 145 articles were screened and 10 studies were included. Risk of bias assessment was performed using the Methodological Index for Non-Randomized Studies (MINORS) criteria. Data summary: Across the studies reviewed, a total of 311 patients were identified with t(11;14) positive RRMM. The overall response rate achieved ranged between 33% and 95.5%. Furthermore, the use of venetoclax has exhibited a favorable adverse effect profile. Side effects included hematological side effects, nausea, vomiting, and diarrhea. Conclusion: Venetoclax demonstrates promising results. When given with drugs like dexamethasone, daratumumab and carfilzomib, a synergistic effect is seen in treating translocation (11:14) positive relapsed/refractory MM. The use of venetoclax in clinical practice can potentially improve outcomes and quality of life in RRMM patients, and future research should continue to explore this promising treatment option.
- Subjects
THERAPEUTIC use of antineoplastic agents; THERAPEUTIC use of monoclonal antibodies; THERAPEUTIC use of protease inhibitors; MULTIPLE myeloma; DIARRHEA; CANCER relapse; ANTINEOPLASTIC agents; CANCER patients; DESCRIPTIVE statistics; SYSTEMATIC reviews; MEDLINE; ONLINE information services; VOMITING; NAUSEA; DEXAMETHASONE; DRUG synergism
- Publication
Journal of Oncology Pharmacy Practice, 2024, Vol 30, Issue 3, p552
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/10781552231218999