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- Title
Synthese von substituierten 1, 2-Malonyl-1,2-dihydrocinnolinen (1,3-Dioxo-2, 3-dihydro-1 H-pyrazolo [1, 2-a] cinnolinen) mit antiinflammatorischen Eigenschaften.
- Authors
Schatz, F.; Wagner-Jauregg, Th.
- Abstract
A new class of antiphlogistic substances is described. They are 4-phenyl-1, 2-dihydrocinnolins diacylated in 1, 2-position by alkylmalonic acids. The compound which pharmacologically has been investigated most thoroughly is cinnopentazone (II). Its synthesis and behaviour towards hydrolytic and oxidative agents are described. Some relations between the chemical structure of these series of substances and their antiinflammatory activity as well as their classification as antiphlogistics according to some model reactions are discussed.
- Publication
Helvetica Chimica Acta, 1968, Vol 51, Issue 8, p1919
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19680510813