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- Title
Evaluation of Silk Fibroin/Gellan Gum Hydrogels with Controlled Molecular Weight through Silk Fibroin Hydrolysis for Tissue Engineering Application.
- Authors
Park, Sunjae; Kim, Soo-In; Choi, Joo-Hee; Kim, Se-Eun; Choe, Seung-Ho; Son, Youngjun; Kang, Tae-woong; Song, Jeong-Eun; Khang, Gilson
- Abstract
Hydrogel is a versatile material that can be manipulated to achieve the desired physicochemical properties, such as stiffness, pore size, and viscoelasticity. Traditionally, these properties have been controlled through parameters such as concentration and pH adjustments. In this study, we focused on exploring the potential of hydrolyzed silk fibroin (HSF) as a molecular weight-modulating agent to control the physicochemical properties of double-composite hydrogels. We developed a synergistic dual-crosslinked hydrogel by combining ionically crosslinked silk fibroin with gellan gum (GG). The hydrolysis of silk fibroin not only enhanced its hydrophilicity but also enabled adjustments in its mechanical properties, including the pore size, initial modulus elasticity, and relaxation time. Moreover, biocompatibility assessments based on cell viability tests confirmed the potential of these hydrogels as biocompatible materials. By highlighting the significance of developing an HSF/GG dual-crosslinked hydrogel, this study contributes to the advancement of novel double-composite hydrogels with remarkable biocompatibility. Overall, our findings demonstrate the capability of controlling the mechanical properties of hydrogels through molecular weight modulation via hydrolysis and highlight the development of a biocompatible HSF/GG dual-crosslinked hydrogel with potential biomedical applications.
- Subjects
GELLAN gum; SILK fibroin; MOLECULAR weights; TISSUE engineering; BIOMEDICAL materials; BIOCOMPATIBILITY; HYDROGELS
- Publication
Molecules, 2023, Vol 28, Issue 13, p5222
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28135222