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- Title
Influence of the transcription factor RORγt on the development of NKp46<sup>+</sup> cell populations in gut and skin.
- Authors
Luci, Carmelo; Reynders, Ana; Ivanov, Ivaylo I; Cognet, Celine; Chiche, Laurent; Chasson, Lionel; Hardwigsen, Jean; Anguiano, Esperanza; Banchereau, Jacques; Chaussabel, Damien; Dalod, Marc; Littman, Dan R; Vivier, Eric; Tomasello, Elena
- Abstract
NKp46+CD3− natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-γ. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3− cells with a diminished capacity to degranulate and produce interferon-γ. In the gut, expression of the transcription factor RORγt, which is involved in the development of lymphoid tissue–inducer cells, defined a previously unknown subset of NKp46+CD3− lymphocytes. Unlike RORγt− lamina propria and dermis natural killer cells, gut RORγt+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue–inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3− cells in innate immunity, lymphoid organization and local tissue repair.
- Publication
Nature Immunology, 2009, Vol 10, Issue 1, p75
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.1681