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- Title
Extrahepatic bile duct atresia and viral involvement.
- Authors
Fjær, Rannveig Bremer; Bruu, Anne-Lise; Nordb, Svein Arne
- Abstract
Fjær RB, Bruu A-L, Nordbø SA. Extrahepatic bile duct atresia and viral involvement.Pediatr Transplantation 2005: 9: 68–73.© 2005 Blackwell MunksgaardSeveral etiological factors have been suggested in the pathogenesis of extrahepatic biliary atresia (EHBA); congenital, metabolic, infectious, and multifactorial. Herein we present a study of 10 children with EHBA, the aim being to explore viral infection as a possible cause of their condition. During a period of 2 yr, all infants with EHBA were included in a study and examined on viral disease on admittance for Kasai operation. In eight of the 10 children and in one parental couple the laboratory results suggested recent or persistent viral infection. Four infections were caused by cytomegalovirus (CMV) and another five by Epstein–Barr virus (EBV). CMV-DNA was detected in two liver biopsies, EBV-DNA in one liver biopsy. In a control group of 10 patients matched by age and tested by PCR in serum and viral antibodies, no sign of viral infections were detected. CMV or EBV infection were present in an unexpectedly high proportion of infants with EHBA, justifying exhaustive examination on viral disease in these children.
- Subjects
EPSTEIN-Barr virus; BILE ducts; DNA; IMMUNOGLOBULINS; BLOOD plasma; VIRAL antibodies
- Publication
Pediatric Transplantation, 2005, Vol 9, Issue 1, p68
- ISSN
1397-3142
- Publication type
Article
- DOI
10.1111/j.1399-3046.2005.00257.x