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- Title
GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events.
- Authors
Pahud de Mortanges, Aurélie; Sinaci, Eldem; Salvador Jr, Dante; Bally, Lia; Muka, Taulant; Wilhelm, Matthias; Bano, Arjola
- Abstract
Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) lower plasma glucose through effects on insulin and glucagon secretion and by decelerating gastric emptying. GLP-1 RAs have many beneficial effects beyond glycemic control, including a protective role on the cardiovascular system. However, underlying mechanisms linking GLP-1 RAs with coronary artery disease are complex and not fully elucidated. In this mini-review, we discuss these mechanisms and subsequent clinical events. Data Sources: We searched PubMed and Google Scholar for evidence on GLP-1 RAs and coronary events. We did not apply restrictions on article type. We reviewed publications for clinical relevance. Synopsis of Content: In the first part, we review the current evidence concerning the role of GLP-1 RAs on potential mechanisms underlying the development of coronary events. Specifically, we discuss the role of GLP-1 RAs on atherosclerosis and vasospasms of epicardial coronary arteries, as well as structural/functional changes of coronary microvasculature. In the second part, we summarize the clinical evidence on the impact of GLP-1 RAs in the prevention of acute and chronic coronary syndromes and coronary revascularization. We conclude by discussing existing gaps in the literature and proposing directions for future research.
- Subjects
GLUCAGON-like peptide-1 agonists; GLUCAGON-like peptide 1; CORONARY artery disease; CARDIOVASCULAR system; ACUTE coronary syndrome; CORONARY arteries; PANCREATIC beta cells; PEPTIDE receptors
- Publication
Frontiers in Pharmacology, 2022, Vol 13, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2022.856111