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- Title
Zur Differenzierurg des Lp(a)-Lipoptoteins mit Hilfe der Agarosegel-Elektrophorese.
- Authors
VOGELBERG, K. H.; UTERMANN, G.; GRIES, F. A.
- Abstract
The Lp(a)-lipoprotein of human serum (d = 1.050-1.090 g/ml) can be separated from other lipoproteins that have pre-β-mobility (VLDL) (d < 1.006 g/ml) by agarose gel electrophoresis. When the serum concentration of this protein is sufficiently high it can be detected as a slowly migrating, double pre-β-band. A double band of this kind was observed in 12% of 758 hyperlipaemic sera. It appeared chiefly in the regression phase of hyperlipoproteinaemia. 138 Sera from hyperlipaemic patients and 71 from normolipaemic persons were studied in the ultracentrifuge. The Lp(a)-lipoprotein detected by electrophoresis in the fraction d > 1.006 g/ml, occurred with the same frequency in both groups (35%). In hyperlipoproteinaemia with increased pre-β-lipoproteins, however, there was a clear correlation between the cholesterol triglyceride quotient and the appearance of the Lp(a)-lipoprotein. The clinical observations show that the Lp(a)-lipoprotein can be subject to considerable individual variations, which appear to depend upon the functional state of the organism. Studies on the purified protein confirmed earlier observations that Lp(a)-lipoprotein is a complex of LDL, Lp(a)-protein, and albumin. Studies on its lipid composition are reported.
- Publication
Clinical Chemistry & Laboratory Medicine, 1973, Vol 11, Issue 7, p291
- ISSN
1434-6621
- Publication type
Article