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- Title
Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles-mumps-rubella-varicella vaccine to children aged 11-21 months.
- Authors
Knuf, Markus; Zepp, Fred; Meyer, Claudius U.; Habermehl, Pirmin; Maurer, Lothar; Burow, Hanns-Michael; Behre, Ulrich; Janssens, Michel; Willems, Paul; Bisanz, Helmtrud; Vetter, Volker; Schmidt-Ott, Ruprecht
- Abstract
This study compared intramuscular and subcutaneous administration of two doses of measles-mumps-rubella-varicella (MMRV) combination vaccine (Priorix-Tetra, GlaxoSmithKline Biologicals) in children. Healthy children (N = 328) were randomised to receive MMRV either intramuscularly or subcutaneously. Reactogenicity was similar between treatment groups for immediate vaccination pain, vaccination site pain, redness and incidence of fever and rashes. Slightly less vaccination site swelling occurred during days 0-3 of the post-vaccination period after intramuscular administration. Seroconversion rates for all components, 42-56 days post-dose 2, ranged from 99.3% to 100% in the intramuscular group and from 98.6% to 100% in the subcutaneous. Cell-mediated immunity data supported the humoral immunogenicity findings. In summary, the MMRV vaccine is well tolerated and highly immunogenic when administered either subcutaneously or intramuscularly to children in the second year of life.
- Subjects
MEASLES; MUMPS; RUBELLA; IMMUNIZATION of children; PREVENTION of communicable diseases; TOGAVIRUS infections; SUBCUTANEOUS injections; COMPARATIVE studies; EXANTHEMA; FEVER; FLUORESCENT antibody technique; INTRAMUSCULAR injections; RESEARCH methodology; MEDICAL cooperation; PAIN; RESEARCH; VIRAL antibodies; COMBINED vaccines; EVALUATION research; MMR vaccines; CHICKENPOX vaccines; ANTIBODY formation
- Publication
European Journal of Pediatrics, 2010, Vol 169, Issue 8, p925
- ISSN
0340-6199
- Publication type
journal article
- DOI
10.1007/s00431-010-1142-6