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- Title
Association between the IVS4G > T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients.
- Authors
Ten¢rio Furgeri, Daniela; Augusto de Lima Marson, Fernando; Fernando Ribeiro, Antonio; Bertuzzo, Carmen Silvia
- Abstract
Background: Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF. Findings: We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients. Conclusions: In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.
- Subjects
DIABETES complications; ENDOCRINE diseases; CARBOHYDRATE intolerance; PANCREATIC diseases; GENETIC disorders
- Publication
BMC Research Notes, 2012, Vol 5, Issue 1, p561
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/1756-0500-5-561