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- Title
Long‐term outcomes of patients with oral cavity cancer receiving postoperative radiotherapy after salvage neck dissection for cervical lymph node recurrence.
- Authors
Fujisawa, Takeshi; Motegi, Atsushi; Hirata, Hidenari; Zenda, Sadamoto; Hojo, Hidehiro; Nakamura, Masaki; Oyoshi, Hidekazu; Tomizawa, Kento; Zhou, Yuzheng; Fukushi, Keiko; Kageyama, Shun‐Ichiro; Enokida, Tomohiro; Okano, Susumu; Tahara, Makoto; Shinozaki, Takeshi; Hayashi, Ryuichi; Matsuura, Kazuto; Akimoto, Tetsuo
- Abstract
Backgrounds: We aimed to clarify the outcomes of postoperative radiotherapy (PORT) after salvage neck dissection for cervical lymph node (LN) recurrence in oral cavity cancer. Methods: We retrospectively evaluated overall survival (OS), recurrence‐free survival (RFS), recurrence patterns, and adverse events of 51 patients with high‐risk features receiving PORT after salvage neck dissection between 2009 and 2019. Results: After a median follow‐up of 7.4 years from PORT initiation, the 7‐year OS and RFS rates were 66.3% (95% CI: 54.0–81.3) and 54.6% (95% CI: 42.1–70.9), respectively. Age <70 years and isolated LN recurrence were significantly associated with longer OS and RFS. Among the 22 patients who experienced recurrence, 14 experienced recurrence within the radiation field. PORT‐related grade 3 acute mucositis (35%) and late adverse events (osteoradionecrosis [4%] and laryngeal stenosis [2%]) were observed. Conclusions: PORT after salvage neck dissection for cervical LN recurrence achieved good survival with acceptable toxicity.
- Subjects
NECK dissection; LYMPHADENECTOMY; ORAL cancer; RADIOTHERAPY; OVERALL survival
- Publication
Head & Neck, 2024, Vol 46, Issue 3, p541
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.27609