We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cardiac Adaptation to Pregnancy in Women With a History of Preeclampsia and a Subnormal Plasma Volume. .
- Authors
Andrietti, Silvia; Kruse, Arnold-Jan; Bekkers, Sebastiaan C. A. M.; Sep, Simone; Spaanderman, Marc; Peeters, Louis L. H.
- Abstract
In former preeclamptics, a subnormal plasma volume (LPV) predisposes to hemodynamic maladaptation to pregnancy. Here, we assessed the initial cardiovascular response to pregnancy in LPV (n = 20), in former preeclamptics with normal plasma volume (NPV) (n = 35) and in parous controls (CONTR) (n = 9) by echocardiography, blood pressure and heart rate (HR), before pregnancy, and by 5 and 7 weeks amenorrhea. Data analysis was by nonparametric tests. LPV differed from NPV and CONTR, by a consistently lower E/A ratio (ratio of peak mitral flow velocity in early diastole [E] and that during atrial contraction [A]) and an early-pregnancy rise in left atrial diameter (LAD). Both NPV and LPV differed from CONTR by an early-pregnancy rise in HR. The consistently lower E/A ratio together with the early-pregnancy LAD rise in LPV indicate diastolic dysfunction. The early-pregnancy rise in HR suggests sympathetic dominance in the autonomic control of the circulation.
- Subjects
PREGNANCY; PREECLAMPSIA; BLOOD plasma; ECHOCARDIOGRAPHY; BLOOD pressure; HEART beat; AMENORRHEA; PATIENTS
- Publication
Reproductive Sciences, 2008, Vol 15, Issue 10, p1059
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1177/1933719108322427