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- Title
The Impact of COVID-19 Pandemic on Disease Severity and Quality of Life in Parkinson's Disease.
- Authors
Saluja, Alvee; Parihar, Jasmine; Garg, Divyani; Dhamija, Rajinder K.
- Abstract
Background: The challenges being faced during the lockdown period may worsen motor or non-motor symptoms in Parkinson's disease (PD). Objective: This study was undertaken to investigate the impact of lockdown on the disease activity, caregiver perceptions and the quality of life of patients with PD. Materials and Methods: This cross-sectional study was conducted from June till September 2020. Sixty-four patients with PD and caregivers were interviewed telephonically after obtaining consent. The responses were recorded by means of a structured questionnaire. Non-motor symptoms scale (NMSS) and the Parkinson Disease Questinnaire-8 (PDQ-8) were applied. PDQ-8 severity index (PDQ-8 SI) scores were expressed as percentage of the raw PDQ-8 score of the total score. Data were analsyed by using SPSS version 20.0. Results: Of 64 patients, 39 (60.9%) were men and 25 (39.1%) were women. The overall median age of the patients was 65 (55.25--69.75) years. The median duration was 48 (30--84) months. Twenty-six (40.6%) patients reported symptomatic worsening during the lockdown period. Slowness in activities of daily living and walking worsened in 15 (57.7%) and 14 (53.8%) patients, respectively, while tremors increased in 12 (46.2%) patients. Mood and sleep disturbances were the most common non-motor symptoms to worsen. Increase in non-motor symptoms and the NMSS total score were independent predictors of PDQ-8 scores. Increase in non-motor symptoms during the lockdown was an independent predictor of the highest quartile of PDQ-8 SI scores. Conclusions: Motor and non-motor symptoms have worsened in patients with PD during the lockdown. The increase in non-motor symptoms was independently associated with poorer quality of life among patients with PD during the lockdown.
- Subjects
CAREGIVER attitudes; CROSS-sectional method; INTERVIEWING; ACTIVITIES of daily living; SEVERITY of illness index; SLEEP disorders; PARKINSON'S disease; QUALITY of life; DESCRIPTIVE statistics; WALKING; AFFECTIVE disorders; QUESTIONNAIRES; STAY-at-home orders; DATA analysis software; COVID-19 pandemic
- Publication
Annals of Indian Academy of Neurology, 2021, Vol 24, Issue 2, p217
- ISSN
0972-2327
- Publication type
Article
- DOI
10.4103/aian.AIAN_1240_20