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- Title
Evaluation of [<sup>18</sup>F]-4-Fluoroantipyrine as a New Blood Flow Tracer for Multiradionuclide Autoradiography.
- Authors
Sako, Kazuhiro; Diksic, Mirko; Kato, Amami; Yamamoto, Y. Lucas; Feindel, William
- Abstract
Summary: This article reports the evaluation of [18F]-4-fluoroantipyrine (FAP) as a quantitative blood flow tracer by comparing blood flow measured with [18F]FAP to that determined simultaneously with [14C]-4-iodoantipyrine (IAP), a standard blood flow tracer, by means of double-tracer autoradiography. The single-pass extraction value (m), which indicates diffusibility of a tracer, was determined according to the procedure described by Crone. The diffusibility of FAP was essentially the same as that of IAP. The brain-blood partition coefficient for FAP was found to be similar to that for IAP, 0.89 ± 0.01. Values of local cerebral blood flow obtained with FAP agree with those determined with IAP. From these results, we concluded that FAP is indeed as good a blood flow tracer as IAP. Since 18F is a positron-emitting radionuclide, it might be a useful tracer for blood flow measurement by positron emission tomography.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1984, Vol 4, Issue 2, p259
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.1984.35