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Mitigating risk in academic preclinical drug discovery.
- Published in:
- Nature Reviews Drug Discovery, 2015, v. 14, n. 4, p. 279, doi. 10.1038/nrd4578
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- Publication type:
- Article
High-throughput screening identifies cell cycle-associated signaling cascades that regulate a multienzyme glucosome assembly in human cells.
- Published in:
- PLoS ONE, 2023, v. 18, n. 8, p. 1, doi. 10.1371/journal.pone.0289707
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- Publication type:
- Article
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.
- Published in:
- Nature Biotechnology, 2009, v. 27, n. 11, p. 1050, doi. 10.1038/nbt.1581
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- Publication type:
- Article
Identification of oxadiazoles as new drug leads for the control of schistosomiasis.
- Published in:
- Nature Medicine, 2008, v. 14, n. 4, p. 407, doi. 10.1038/nm1737
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- Publication type:
- Article
A coincidence reporter-gene system for high-throughput screening.
- Published in:
- Nature Methods, 2012, v. 9, n. 10, p. 937, doi. 10.1038/nmeth.2170
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- Publication type:
- Article
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.
- Published in:
- Nature, 1992, v. 359, n. 6391, p. 147, doi. 10.1038/359147a0
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- Publication type:
- Article
A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of <i>gsp</i>.
- Published in:
- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090766
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- Publication type:
- Article
Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays.
- Published in:
- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0057888
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- Publication type:
- Article
A 1,536-Well cAMP Assay for Gs- and Gi-Coupled Receptors Using Enzyme Fragmentation Complementation.
- Published in:
- Assay & Drug Development Technologies, 2004, v. 2, n. 1, p. 39
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- Publication type:
- Article
A β-Lactamase-Dependent Gal4-Estrogen Receptor β Transactivation Assay for the Ultra-High Throughput Screening of Estrogen Receptor β Agonists in a 3,456-Well Format.
- Published in:
- Assay & Drug Development Technologies, 2003, v. 1, n. 6, p. 789
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- Publication type:
- Article
A Fully Automated [<sup>35</sup>S]GTPγS Scintillation Proximity Assay for the High-Throughput Screening of G<sub>i</sub>-Linked G Protein-Coupled Receptors.
- Published in:
- Assay & Drug Development Technologies, 2003, v. 1, n. 2, p. 261
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- Publication type:
- Article
Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening.
- Published in:
- Environmental Health Perspectives, 2008, v. 116, n. 3, p. 284, doi. 10.1289/ehp.10727
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- Publication type:
- Article
A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology.
- Published in:
- PLoS ONE, 2020, v. 15, n. 4, p. 1, doi. 10.1371/journal.pone.0226661
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- Publication type:
- Article
Establishing an RNA interference (RNAi) screen for neuroprotection of dopaminergic neurons in Caenorhabditis elegans models of Parkinson's disease.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3837
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- Publication type:
- Article
Development of a dopaminergic neurodegeneration assay using laser cytometry of Caenorhabditis elegans models of Parkinson's disease.
- Published in:
- FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02267
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- Publication type:
- Article
Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.
- Published in:
- Nature Communications, 2017, v. 8, n. 4, p. 14932, doi. 10.1038/ncomms14932
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- Publication type:
- Article
Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes.
- Published in:
- Nature Communications, 2015, v. 6, n. 12, p. 8898, doi. 10.1038/ncomms9898
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- Publication type:
- Article
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
- Published in:
- Science Translational Medicine, 2019, v. 11, n. 500, p. 1, doi. 10.1126/scitranslmed.aav5464
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- Publication type:
- Article
Improving Success by Balanced Critical Evaluations of Assay Methods.
- Published in:
- Assay & Drug Development Technologies, 2010, v. 8, n. 4, p. 1, doi. 10.1089/adt.2010.0804.com
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- Publication type:
- Article
A Multiplex Calcium Assay for Identification of GPCR Agonists and Antagonists.
- Published in:
- Assay & Drug Development Technologies, 2010, v. 8, n. 3, p. 367, doi. 10.1089/adt.2009.0245
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- Publication type:
- Article
A High-Throughput 1,536-Well Luminescence Assay for Glutathione S-Transferase Activity.
- Published in:
- Assay & Drug Development Technologies, 2010, v. 8, n. 2, p. 200, doi. 10.1089/adt.2009.0248
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- Publication type:
- Article
Assay, Preclinical, and Clinical Brick Walls and Opportunities for System Change Through GRANDRx.
- Published in:
- Assay & Drug Development Technologies, 2010, v. 8, n. 2, p. 128, doi. 10.1089/adt.2010.0802.rt
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- Publication type:
- Article
Comparison of Bioluminescent Kinase Assays Using Substrate Depletion and Product Formation.
- Published in:
- Assay & Drug Development Technologies, 2009, v. 7, n. 6, p. 606, doi. 10.1089/adt.2009.0230
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- Publication type:
- Article
A Dual-Fluorescence High-Throughput Cell Line System for Probing Multidrug Resistance.
- Published in:
- Assay & Drug Development Technologies, 2009, v. 7, n. 3, p. 233, doi. 10.1089/adt.2008.165
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- Publication type:
- Article
Identification of Pregnane X Receptor Ligands Using Time-Resolved Fluorescence Resonance Energy Transfer and Quantitative High-Throughput Screening.
- Published in:
- Assay & Drug Development Technologies, 2009, v. 7, n. 2, p. 143, doi. 10.1089/adt.2009.193
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- Publication type:
- Article
A Robotic Platform for Quantitative High-Throughput Screening.
- Published in:
- Assay & Drug Development Technologies, 2008, v. 6, n. 5, p. 637, doi. 10.1089/adt.2008.150
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- Publication type:
- Article
A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoniThioredoxin Glutathione Reductase.
- Published in:
- Assay & Drug Development Technologies, 2008, v. 6, n. 4, p. 551, doi. 10.1089/adt.2008.149
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- Publication type:
- Article
A Fluorescence-Based Thiol Quantification Assay for Ultra-High-Throughput Screening for Inhibitors of Coenzyme A Production.
- Published in:
- Assay & Drug Development Technologies, 2008, v. 6, n. 3, p. 361, doi. 10.1089/adt.2007.105
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- Publication type:
- Article
Evaluation of Micro-Parallel Liquid Chromatography as a Method for HTS-Coupled Actives Verification.
- Published in:
- Assay & Drug Development Technologies, 2007, v. 5, n. 6, p. 815, doi. 10.1089/adt.2007.097
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- Publication type:
- Article
A Cell-Based Assay for IBαStabilization Using A Two-Color Dual Luciferase-Based Sensor.
- Published in:
- Assay & Drug Development Technologies, 2007, v. 5, n. 1, p. 85, doi. 10.1089/adt.2006.048
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- Publication type:
- Article
A Macrocyclic Peptide Library with a Structurally Constrained Cyclopropane‐containing Building Block Leads to Thiol‐independent Inhibitors of Phosphoglycerate Mutase.
- Published in:
- Chemistry - An Asian Journal, 2020, v. 15, n. 17, p. 2631, doi. 10.1002/asia.202000700
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- Publication type:
- Article
qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data.
- Published in:
- Journal of Cheminformatics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13321-023-00717-9
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- Publication type:
- Article
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
- Published in:
- PLoS ONE, 2019, v. 14, n. 7, p. 1, doi. 10.1371/journal.pone.0218897
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- Publication type:
- Article
A PDZ domain-based assay for measuring HIV protease activity: Assay design considerations.
- Published in:
- Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 3, p. 458, doi. 10.1110/ps.0235603
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- Publication type:
- Article
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
- Published in:
- Nature Chemical Biology, 2009, v. 5, n. 10, p. 765, doi. 10.1038/nchembio.215
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- Publication type:
- Article
Reporting data from high-throughput screening of small-molecule libraries.
- Published in:
- 2007
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- Publication type:
- Editorial
High-throughput screening assays for the identification of chemical probes.
- Published in:
- Nature Chemical Biology, 2007, v. 3, n. 8, p. 466, doi. 10.1038/nchembio.2007.17
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- Publication type:
- Article
Weighted Feature Significance: A Simple, Interpretable Model of Compound Toxicity Based on the Statistical Enrichment of Structural Features.
- Published in:
- Toxicological Sciences, 2009, v. 112, n. 2, p. 385, doi. 10.1093/toxsci/kfp231
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- Publication type:
- Article
Identification of Chemical Compounds that Induce HIF-1α Activity.
- Published in:
- Toxicological Sciences, 2009, v. 112, n. 1, p. 153, doi. 10.1093/toxsci/kfp123
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- Publication type:
- Article
Directed evolution of PDZ variants to generate high-affinity detection reagents.
- Published in:
- PEDS: Protein Engineering, Design & Selection, 2005, v. 18, n. 4, p. 165, doi. 10.1093/protein/gzi018
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- Publication type:
- Article
Directed evolution of PDZ variants to generate high-affinity detection reagents.
- Published in:
- PEDS: Protein Engineering, Design & Selection, 2005, v. 18, n. 4, p. 165, doi. 10.1093/protein/gzi018
- By:
- Publication type:
- Article