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- Title
Synthesis and Biological Activities of Arylspiroborates Derived from 2,3-Dihydroxynaphthalene.
- Authors
Geier, Michael J.; Bowes, Eric G.; Lee, Graham M.; Li, Haoxin; O'Neill, Taryn; Flewelling, Andrew; Vogels, Christopher M.; Decken, Andreas; Gray, Christopher A.; Westcott, Stephen A.
- Abstract
ABSTRACT A family of arylspiroborate compounds has been prepared from 2,3-dihydroxynaphthalene and characterized fully using multinuclear NMR spectroscopy and elemental analyses. Single crystal X-ray diffraction studies were carried out on the tetramethylammonium ( 4) and calcium ( 6) derivatives. Compound 6 represents the first structurally characterized example of a calcium arylspiroborate salt. All compounds showed modest antifungal and antimycobacterial activities. These results have revealed a new class of compounds that should be further developed to design more potent and selective antitubercular agents. © 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:116-123, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21072
- Publication
Heteroatom Chemistry, 2013, Vol 24, Issue 2, p116
- ISSN
1042-7163
- Publication type
Article
- DOI
10.1002/hc.21072