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- Title
Variations in <sup>123</sup>I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: a need for standardisation and validation.
- Authors
Verberne, Hein J.; Habraken, Jan B.A.; van Eck-Smit, Berthe L.F.; Agostini, Denis; Jacobson, Arnold F.
- Abstract
There is lack of validation and standardisation of acquisition parameters for myocardial 123I-metaiodobenzylguanidine (MIBG). This lack of standardisation hampers large scale implementation of 123I-MIBG parameters in the evaluation of patients with chronic heart failure (CHF). In a retrospective multi-centre study 123I-MIBG planar scintigrams obtained on 290 CHF patients (82% male; 58% dilated cardiomyopathy; New York Heart Association [NYHA classification] > I) were reanalysed to determine the late heart-to-mediastinum ratio (H/M). There was a large variation in acquisition parameters. Multivariate forward stepwise regression showed that a significant proportion (31%, p < 0.001) of the variation in late H/M could be explained by a model containing patient-related variables and acquisition parameters. Left ventricular ejection fraction ( p < 0.001), type of collimation ( p < 0.001), acquisition duration ( p = 0.001), NYHA class ( p = 0.028) and age ( p = 0.034) were independent predictors of late H/M. Acquisitions parameters are independent contributors to the variation of semi-quantitative measurements of cardiac 123I-MIBG uptake. Improved standardisation of cardiac 123I-MIBG imaging parameters would contribute to increased clinical applicability for this procedure.
- Subjects
HEART failure; CARDIOMYOPATHIES; MIBG (Chemical); HEART diseases; STANDARDIZATION
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2008, Vol 35, Issue 3, p547
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-007-0611-2