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- Title
Escaping nuclear decay: the significance of mRNA export for gene expression.
- Authors
Tudek, Agnieszka; Schmid, Manfred; Jensen, Torben Heick
- Abstract
In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on messenger RNA (mRNA) functionality. It is well established that control of protein-coding gene expression in eukaryotes employs the regulated production of mRNA, its intra-cellular transfer to cytoplasmic ribosomes and final transcript degradation. Despite a rich body of literature on these events, an involvement of nuclear RNA decay systems remains largely unexplored. Instead, nuclear RNA degradation is often considered a quality control precaution engaged primarily in ridding cells of aberrantly processed transcripts and spurious non-coding RNA. Recent research from human and budding yeast cells, however, demonstrates that even protein-coding transcripts fall prey to nuclear decay and that this is countered by their nuclear export. Here, we outline the potential of nuclear polyA-binding proteins in tuning levels of cellular mRNA to maintain transcript homeostasis.
- Subjects
RIBOSOMAL proteins; RADIOACTIVE decay; GENE expression; MESSENGER RNA; NUCLEAR nonproliferation
- Publication
Current Genetics, 2019, Vol 65, Issue 2, p473
- ISSN
0172-8083
- Publication type
Article
- DOI
10.1007/s00294-018-0913-x