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- Title
Identification of Calcium Hydrogen Phosphate Dihydrate Crystals in Human Fibrocartilage.
- Authors
McCARTY, DANIEL J.; GATTER, ROBERT A.
- Abstract
RECENTLY, we identified microcrystalline calcium pyro-phosphate dihydrate in certain pathological human synovial fluids1. Roentgenograms of the involved joints showed calcifications in cartilaginous structures; the clinical picture was distinctive enough to suggest a specific syndrome, which we named 'pseudogout'2. In two cases multiple cartilages were examined post mortem and most contained localized deposits of these crystals3. The interplanar spacings found on X-ray diffraction powder pattern are virtually identical with those reported for calcium pyrophosphate dihydrate prepared by Brown et al.4 by hydrolytic degradation of calcium polymetaphosphate gel. Monoclinic and triclinic dimorphs have been identified by these same workers5. In human material, the triclinic dimorph predominates although interplanar spacings indicative of the monoclinic form are detected frequently6.
- Publication
Nature, 1964, Vol 201, Issue 4917, p391
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/201391b0