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Computational model for fetal skeletal defects potentially linked to disruption of retinoic acid signaling.
Published in:
Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.971296
By:
- Pierro, Jocylin D.;
- Ahir, Bhavesh K.;
- Baker, Nancy C.;
- Kleinstreuer, Nicole C.;
- Menghang Xia;
- Knudsen, Thomas B.
Publication type:
Article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.
Published in:
Nature Biotechnology, 2014, v. 32, n. 6, p. 583, doi. 10.1038/nbt.2914
By:
- Kleinstreuer, Nicole C;
- Yang, Jian;
- Berg, Ellen L;
- Knudsen, Thomas B;
- Richard, Ann M;
- Martin, Matthew T;
- Reif, David M;
- Judson, Richard S;
- Polokoff, Mark;
- Dix, David J;
- Kavlock, Robert J;
- Houck, Keith A
Publication type:
Article
Adenosine levels in the postimplantation mouse uterus: Quantitation by HPLC-fluorometric detection and spatiotemporal regulation by 5′-nucleotidase and adenosine deaminase.
Published in:
Developmental Dynamics, 1992, v. 194, n. 2, p. 155, doi. 10.1002/aja.1001940208
By:
- Blackburn, Michael R.;
- Gao, Xiang;
- Airhart, Mark J.;
- Skalko, Richard G.;
- Thompson, Linda F.;
- Knudsen, Thomas B.
Publication type:
Article
Identification of Estrogen Target Genes during Zebrafish Embryonic Development through Transcriptomic Analysis.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079020
By:
- Hao, Ruixin;
- Bondesson, Maria;
- Singh, Amar V.;
- Riu, Anne;
- McCollum, Catherine W.;
- Knudsen, Thomas B.;
- Gorelick, Daniel A.;
- Gustafsson, Jan-Åke
Publication type:
Article
Lasting Effects on Body Weight and Mammary Gland Gene Expression in Female Mice upon Early Life Exposure to <i>n</i>-3 but Not <i>n</i>-6 High-Fat Diets.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0055603
By:
- Luijten, Mirjam;
- Singh, Amar V.;
- Bastian, Caleb A.;
- Westerman, Anja;
- Pisano, M. Michele;
- Pennings, Jeroen L. A.;
- Verhoef, Aart;
- Green, Maia L.;
- Piersma, Aldert H.;
- de Vries, Annemieke;
- Knudsen, Thomas B.
Publication type:
Article
Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis.
Published in:
PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038713
By:
- Christopher States, J.;
- Singh, Amar V.;
- Knudsen, Thomas B.;
- Rouchka, Eric C.;
- Ngalame, Ntube O.;
- Arteel, Gavin E.;
- Yulan Piao;
- Ko, Minoru S. H.
Publication type:
Article
Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay.
Published in:
PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0018540
By:
- Chandler, Kelly J.;
- Barrier, Marianne;
- Jeffay, Susan;
- Nichols, Harriette P.;
- Kleinstreuer, Nicole C.;
- Singh, Amar V.;
- Reif, David M.;
- Sipes, Nisha S.;
- Judson, Richard S.;
- Dix, David J.;
- Kavlock, Robert;
- Hunter III, Edward S.;
- Knudsen, Thomas B.
Publication type:
Article
Improving Predictive Modeling in Pediatric Drug Development: Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling.
Published in:
Annals of the New York Academy of Sciences, 2005, v. 1053, n. 1, p. 505, doi. 10.1196/annals.1344.044
By:
- SLIKKER, WILLIAM;
- YOUNG, JOHN F.;
- CORLEY, RICHARD A.;
- DORMAN, DAVID C.;
- CONOLLY, RORY B.;
- KNUDSEN, THOMAS B.;
- ERSTAD, BRIAN L.;
- LUECKE, RICHARD H.;
- FAUSTMAN, ELAINE M.;
- TIMCHALK, CHARLES;
- MATTISON, DONALD R.
Publication type:
Article
Blood-brain barrier development: Systems modeling and predictive toxicology.
Published in:
Birth Defects Research, 2017, v. 109, n. 20, p. 1680, doi. 10.1002/bdr2.1180
By:
- Saili, Katerine S.;
- Zurlinden, Todd J.;
- Schwab, Andrew J.;
- Silvin, Aymeric;
- Baker, Nancy C.;
- Hunter, E. Sidney;
- Ginhoux, Florent;
- Knudsen, Thomas B.
Publication type:
Article
Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".
Published in:
2017
By:
- Houck, Keith A.;
- Judson, Richard S.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- Richard, Ann M.;
- Crofton, Kevin M.;
- Simeonov, Anton;
- Paules, Richard S.;
- Bucher, John R.;
- Thomas, Russell S.
Publication type:
Letter to the Editor
Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes.
Published in:
Environmental Health Perspectives, 2016, v. 124, n. 7, p. 1050, doi. 10.1289/ehp.1510385
By:
- Leung, Maxwell C. K.;
- Phuong, Jimmy;
- Baker, Nancy C.;
- Sipes, Nisha S.;
- Klinefelter, Gary R.;
- Martin, Matthew T.;
- McLaurin, Keith W.;
- Setzer, R. Woodrow;
- Perreault Darney, Sally;
- Judson, Richard S.;
- Knudsen, Thomas B.
Publication type:
Article
Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.
Published in:
Environmental Health Perspectives, 2016, v. 124, n. 7, p. 910, doi. 10.1289/ehp.1409029
By:
- Shah, Imran;
- Setzer, R. Woodrow;
- Jack, John;
- Houck, Keith A.;
- Judson, Richard S.;
- Knudsen, Thomas B.;
- Jie Liu;
- Martin, Matthew T.;
- Reif, David M.;
- Richard, Ann M.;
- Thomas, Russell S.;
- Crofton, Kevin M.;
- Dix, David J.;
- Kavlock, Robert J.
Publication type:
Article
A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function.
Published in:
Environmental Health Perspectives, 2013, v. 121, n. 6, p. 717, doi. 10.1289/ehp.1206301
By:
- Allard, Patrick;
- Kleinstreuer, Nicole C.;
- Knudsen, Thomas B.;
- Colaiácovo, Monica P.
Publication type:
Article
Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals.
Published in:
2013
By:
- Rotroff, Daniel M.;
- Dix, David J.;
- Houck, Keith A.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- McLaurin, Keith W.;
- Reif, David M.;
- Crofton, Kevin M.;
- Singh, Amar V.;
- Menghang Xia;
- Ruili Huang;
- Judson, Richard S.
Publication type:
Journal Article
Supplemental Material. Using in Vitro High-Throughput Screening Assays to Identify Potential Endocrine Disrupting Chemicals.
Published in:
Environmental Health Perspectives, 2013, v. 121, n. 1, p. 1, doi. 10.1289/ehp.1205065
By:
- Rotroff, Daniel M.;
- Dix, David J.;
- Houck, Keith A.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- McLaurin, Keith W.;
- Reif, David M.;
- Crofton, Kevin M.;
- Singh, Amar V.;
- Menghang Xia;
- Ruili Huang;
- Judson, Richard S.
Publication type:
Article
Environmental Impact on Vascular Development Predicted by High-Throughput Screening.
Published in:
2011
By:
- Kleinstreuer, Nicole C.;
- Judson, Richard S.;
- Reif, David M.;
- Sipes, Nisha S.;
- Singh, Amar V.;
- Chandler, Kelly J.;
- DeWoskin, Rob;
- Dix, David J.;
- Kavlock, Robert J.;
- Knudsen, Thomas B.
Publication type:
Journal Article
Environmental Impact on Vascular Development Predicted by High-Throughput Screening.
Published in:
Environmental Health Perspectives, 2011, v. 119, n. 11, p. 1596, doi. 10.1289/ehp.1103412
By:
- Kleinstreuer, Nicole C.;
- Judson, Richard S.;
- Reif, David M.;
- Sipes, Nisha S.;
- Singh, Amar V.;
- Chandler, Kelly J.;
- DeWoskin, Rob;
- Dix, David J.;
- Kavlock, Robert J.;
- Knudsen, Thomas B.
Publication type:
Article
Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data.
Published in:
Environmental Health Perspectives, 2010, v. 118, n. 12, p. 1714, doi. 10.1289/ehp.1002180
By:
- Reif, David M.;
- Martin, Matthew T.;
- Tan, Shirlee W.;
- Houck, Keith A.;
- Judson, Richard S.;
- Richard, Ann M.;
- Knudsen, Thomas B.;
- Dix, David J.;
- Kavlock, Robert J.
Publication type:
Article
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project.
Published in:
Environmental Health Perspectives, 2010, v. 118, n. 4, p. 485, doi. 10.1289/ehp.0901392
By:
- Judson, Richard S.;
- Houck, Keith A.;
- Kavlock, Robert J.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- Mortensen, Holly M.;
- Reif, David M.;
- Rotroff, Daniel M.;
- Shah, Imran;
- Richard, Ann M.;
- Dix, David J.
Publication type:
Article
Society for birth defects research and prevention's multidisciplinary research needs workshop 2022: A call to action.
Published in:
Birth Defects Research, 2023, v. 115, n. 10, p. 959, doi. 10.1002/bdr2.2186
By:
- Basu, Madhumita;
- Howdeshell, Kembra L.;
- Rasmussen, Sonja A.;
- Rychlik, Kristal A.;
- Knudsen, Thomas B.;
- Shuey, Dana L.;
- Slikker, William
Publication type:
Article
Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues.
Published in:
Birth Defects Research, 2022, v. 114, n. 16, p. 1037, doi. 10.1002/bdr2.2019
By:
- Chang, Xiaoqing;
- Palmer, Jessica;
- Lumen, Annie;
- Lee, Un Jung;
- Ceger, Patricia;
- Mansouri, Kamel;
- Sprankle, Catherine;
- Donley, Elizabeth;
- Bell, Shannon;
- Knudsen, Thomas B.;
- Wambaugh, John;
- Cook, Bethany;
- Allen, David;
- Kleinstreuer, Nicole
Publication type:
Article
Single‐cell profiling for advancing birth defects research and prevention.
Published in:
Birth Defects Research, 2021, v. 113, n. 7, p. 546, doi. 10.1002/bdr2.1870
By:
- Knudsen, Thomas B.;
- Spielmann, Malte;
- Megason, Sean G.;
- Faustman, Elaine M.
Publication type:
Article
Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature.
Published in:
Birth Defects Research, 2020, v. 112, n. 1, p. 19, doi. 10.1002/bdr2.1581
By:
- Baker, Nancy C.;
- Sipes, Nisha S.;
- Franzosa, Jill;
- Belair, David G.;
- Abbott, Barbara D.;
- Judson, Richard S.;
- Knudsen, Thomas B.
Publication type:
Article
Reprogramming of genetic networks during initiation of the Fetal Alcohol SyndromeGEO dataset (GDS): GSE1074.
Published in:
Developmental Dynamics, 2007, v. 236, n. 2, p. 613, doi. 10.1002/dvdy.21048
By:
- Maia L. Green;
- Amar V. Singh;
- Yihzi Zhang;
- Kimberly A. Nemeth;
- Kathleen K. Sulik;
- Thomas B. Knudsen
Publication type:
Article
Consensus Report on the Future of Animal- Free Systemic Toxicity Testing.
Published in:
Altex, 2014, v. 31, n. 3, p. 341, doi. 10.14573/altex.1406091
By:
- Leist, Marcel;
- Hasiwa, Nina;
- Rovida, Costanza;
- Daneshian, Mardas;
- Basketter, David;
- Kimber, Ian;
- Clewell, Harvey;
- Gocht, Tilman;
- Goldberg, Alan;
- Busquet, Francois;
- Rossi, Anna-Maria;
- Schwarz, Michael;
- Stephens, Martin;
- Taalman, Rob;
- Knudsen, Thomas B.;
- McKim, James;
- Harris, Georgina;
- Pamies, David;
- Hartung, Thomas
Publication type:
Article
A Roadmap for the Development of Alternative (Non-Animal) Methods for Systemic Toxicity Testing.
Published in:
Altex, 2012, v. 29, n. 1, p. 5, doi. 10.14573/altex.2012.1.003
By:
- Basketter, David A.;
- Clewell, Harvey;
- Kimber, Ian;
- Rossi, Annamaria;
- Blaauboer, Bas;
- Burrier, Robert;
- Daneshian, Mardas;
- Eskes, Chantra;
- Goldberg, Alan;
- Hasiwa, Nina;
- Hoffmann, Sebastian;
- Jaworska, Joanna;
- Knudsen, Thomas B.;
- Landsiedel, Robert;
- Leist, Marcel;
- Locke, Paul;
- Maxwell, Gavin;
- McKim, James;
- McVey, Emily A.;
- Ouédraogo, Gladys
Publication type:
Article
Development and validation of CYP26A1 inhibition assay for high‐throughput screening.
Published in:
Biotechnology Journal, 2024, v. 19, n. 6, p. 1, doi. 10.1002/biot.202300659
By:
- Sakamuru, Srilatha;
- Ma, Dongping;
- Pierro, Jocylin D.;
- Baker, Nancy C.;
- Kleinstreuer, Nicole;
- Cali, James J.;
- Knudsen, Thomas B.;
- Xia, Menghang
Publication type:
Article
FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children.
Published in:
Toxicological Sciences, 2021, v. 180, n. 2, p. 198, doi. 10.1093/toxsci/kfab013
By:
- Knudsen, Thomas B;
- Fitzpatrick, Suzanne Compton;
- Abrew, K Nadira De;
- Birnbaum, Linda S;
- Chappelle, Anne;
- Daston, George P;
- Dolinoy, Dana C;
- Elder, Alison;
- Euling, Susan;
- Faustman, Elaine M;
- Fedinick, Kristi Pullen;
- Franzosa, Jill A;
- Haggard, Derik E;
- Haws, Laurie;
- Kleinstreuer, Nicole C;
- Louis, Germaine M Buck;
- Mendrick, Donna L;
- Rudel, Ruthann;
- Saili, Katerine S;
- Schug, Thaddeus T
Publication type:
Article
Corrigendum to: "Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity".
Published in:
Toxicological Sciences, 2020, v. 177, n. 1, p. 301, doi. 10.1093/toxsci/kfaa064
By:
- Zurlinden, Todd J;
- Saili, Katerine S;
- Rush, Nathaniel;
- Kothiya, Parth;
- Judson, Richard S;
- Houck, Keith A;
- Hunter, E Sidney;
- Baker, Nancy C;
- Palmer, Jessica A;
- Thomas, Russell S;
- Knudsen, Thomas B
Publication type:
Article
Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity.
Published in:
Toxicological Sciences, 2020, v. 174, n. 2, p. 189, doi. 10.1093/toxsci/kfaa014
By:
- Zurlinden, Todd J;
- Saili, Katerine S;
- Rush, Nathaniel;
- Kothiya, Parth;
- Judson, Richard S;
- Houck, Keith A;
- Hunter, E Sidney;
- Baker, Nancy C;
- Palmer, Jessica A;
- Thomas, Russell S;
- Knudsen, Thomas B
Publication type:
Article
Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.
Published in:
Toxicological Sciences, 2019, v. 169, n. 2, p. 317, doi. 10.1093/toxsci/kfz058
By:
- Thomas, Russell S;
- Bahadori, Tina;
- Buckley, Timothy J;
- Cowden, John;
- Deisenroth, Chad;
- Dionisio, Kathie L;
- Frithsen, Jeffrey B;
- Grulke, Christopher M;
- Gwinn, Maureen R;
- Harrill, Joshua A;
- Higuchi, Mark;
- Houck, Keith A;
- Hughes, Michael F;
- Hunter, E Sidney;
- Isaacs, Kristin K;
- Judson, Richard S;
- Knudsen, Thomas B;
- Lambert, Jason C;
- Linnenbrink, Monica;
- Martin, Todd M
Publication type:
Article
FutureTox III: Bridges for Translation.
Published in:
Toxicological Sciences, 2017, v. 155, n. 1, p. 22, doi. 10.1093/toxsci/kfw194
By:
- Juberg, Daland R.;
- Knudsen, Thomas B.;
- Sander, Miriam;
- Beck, Nancy B.;
- Faustman, Elaine M.;
- Mendrick, Donna L.;
- Fowle III, John R.;
- Hartung, Thomas;
- Tice, Raymond R.;
- Lemazurier, Emmanuel;
- Becker, Richard A.;
- Fitzpatrick, Suzanne Compton;
- Daston, George P.;
- Harrill, Alison;
- Hines, Ronald N.;
- Keller, Douglas A.;
- Lipscomb, John C.;
- Watson, David;
- Bahadori, Tina;
- Crofton, Kevin M.
Publication type:
Article
Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.
Published in:
Toxicological Sciences, 2016, v. 152, n. 2, p. 323, doi. 10.1093/toxsci/kfw092
By:
- Judson, Richard;
- Houck, Keith;
- Martin, Matt;
- Richard, Ann M.;
- Knudsen, Thomas B.;
- Shah, Imran;
- Little, Stephen;
- Wambaugh, John;
- Setzer, R. Woodrow;
- Kothya, Parth;
- Jimmy Phuong;
- Filer, Dayne;
- Smith, Doris;
- Reif, David;
- Rotroff, Daniel;
- Kleinstreuer, Nicole;
- Sipes, Nisha;
- Menghang Xia;
- Ruili Huang;
- Crofton, Kevin
Publication type:
Article
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.
Published in:
Toxicological Sciences, 2015, v. 148, n. 1, p. 137, doi. 10.1093/toxsci/kfv168
By:
- Judson, Richard S.;
- Magpantay, Felicia Maria;
- Chickarmane, Vijay;
- Haskell, Cymra;
- Tania, Nessy;
- Taylor, Jean;
- Xia, Menghang;
- Huang, Ruili;
- Rotroff, Daniel M.;
- Filer, Dayne L.;
- Houck, Keith A.;
- Martin, Matthew T.;
- Sipes, Nisha;
- Richard, Ann M.;
- Mansouri, Kamel;
- Setzer, R. Woodrow;
- Knudsen, Thomas B.;
- Crofton, Kevin M.;
- Thomas, Russell S.
Publication type:
Article
FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology.
Published in:
Toxicological Sciences, 2015, v. 143, n. 2, p. 256, doi. 10.1093/toxsci/kfu234
By:
- Knudsen, Thomas B.;
- Keller, Douglas A.;
- Sander, Miriam;
- Carney, Edward W.;
- Doerrer, Nancy G.;
- Eaton, David L.;
- Fitzpatrick, Suzanne Compton;
- Hastings, Kenneth L.;
- Mendrick, Donna L.;
- Tice, Raymond R.;
- Watkins, Paul B.;
- Whelan, Maurice
Publication type:
Article
In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis.
Published in:
Toxicological Sciences, 2013, v. 131, n. 1, p. 40, doi. 10.1093/toxsci/kfs285
By:
- Kleinstreuer, Nicole C.;
- Dix, David J.;
- Houck, Keith A.;
- Kavlock, Robert J.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- Paul, Katie B.;
- Reif, David M.;
- Crofton, Kevin M.;
- Hamilton, Kerry;
- Hunter, Ronald;
- Shah, Imran;
- Judson, Richard S.
Publication type:
Article
Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity.
Published in:
Toxicological Sciences, 2012, v. 130, n. 2, p. 440, doi. 10.1093/toxsci/kfs281
By:
- Dix, David J.;
- Houck, Keith A.;
- Judson, Richard S.;
- Kleinstreuer, Nicole C.;
- Knudsen, Thomas B.;
- Martin, Matthew T.;
- Reif, David M.;
- Richard, Ann M.;
- Shah, Imran;
- Sipes, Nisha S.;
- Kavlock, Robert J.
Publication type:
Article
Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data.
Published in:
Toxicological Sciences, 2011, v. 124, n. 1, p. 109, doi. 10.1093/toxsci/kfr220
By:
- Sipes, Nisha S.;
- Martin, Matthew T.;
- Reif, David M.;
- Kleinstreuer, Nicole C.;
- Judson, Richard S.;
- Singh, Amar V.;
- Chandler, Kelly J.;
- Dix, David J.;
- Kavlock, Robert J.;
- Knudsen, Thomas B.
Publication type:
Article

Found: 38