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- Title
The DOMON domains are involved in heme and sugar recognition.
- Authors
Iyer, Lakshminarayan M.; Anantharaman, Vivek; Aravind, L.
- Abstract
We expand the functionally uncharacterized DOMON domain superfamily to identify several novel families, including the first prokaryotic representatives. Using several computational tools we show that it is involved in ligand binding—either as heme- or sugar-binding domains. We present evidence that the DOMON domain along with the DM13 domain comprises a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. Other novel versions might function as sugar sensors of histidine kinases of bacterial two component systems.
- Subjects
PROKARYOTES; HEME; HISTIDINE; CHARGE exchange; LIGAND binding (Biochemistry)
- Publication
Bioinformatics, 2007, Vol 23, Issue 20, p2660
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btm411