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- Title
Halocyclization of 2-(2-(4-[allylamino(thioxo)methyl]piperazin-1-yl)ethyl)-1 H-benzo[ de]isoquinoline-1,3(2 H)-dione.
- Authors
Zborovskii, Yu. L.; Orysyk, V. V.; Staninets, V. I.; Bon', V. V.
- Abstract
Cyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1 H-benzo[ de]isoquinoline-1,3(2 H)-dione by the action of iodine, bromine, or sulfuryl chloride gave 2-(2-{4-[4,5-dihydro-5-(halomethyl)-thiazol-2-yl]piperazin-1-yl}ethyl)-1 H-benzo[ de]isoquinoline-1,3(2 H)-dione hydrohalides which were converted into 2-{2-[4-(5-methylthiazol-2-yl)piperazin-1-yl]ethyl}-1 H-benzo[ de]isoquinoline-1,3(2 H)-dione.
- Subjects
ELECTROPHILES; HETEROCYCLIC compounds; RING formation (Chemistry); ANTINEOPLASTIC agents; PIPERAZINE
- Publication
Russian Journal of Organic Chemistry, 2011, Vol 47, Issue 6, p881
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S107042801106008X