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- Title
Characterizing the effects of type I collagen alterations on respiratory function in mouse models with varying severity of osteogenesis imperfecta.
- Authors
Zaheer, Wajeeha; Sadat‐Afjeh, Niki; Ragunayakam, Nandhitha
- Abstract
Similarly, female I Col1a2 SP +/G610C sp i mice displayed alveolar simplification, increased MLI and reduced ISA, although this was not significant in female I oim/+ i or I oim/oim i mice. Keywords: alveolar simplification; collagen I; emphysema; histology; mouse model; osteogenesis imperfecta; respirology; sexual dimorphism; spirometry EN alveolar simplification collagen I emphysema histology mouse model osteogenesis imperfecta respirology sexual dimorphism spirometry 401 402 2 02/03/23 20230201 NES 230201 Osteogenesis imperfecta (OI), also known as brittle bone disease, occurs as a result of type I collagen alterations.
- Subjects
OSTEOGENESIS imperfecta; LABORATORY mice; ANIMAL disease models; COLLAGEN
- Publication
Journal of Physiology, 2023, Vol 601, Issue 3, p401
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP284132