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- Title
(1) Gene-knockout (GT-KO) heterotopic cardiac xenotransplantation: are GT-KO pigs essential for successful clinical xenotransplantation?
- Authors
McGregor, Christopher G. A.; Tazelaar, Henry D.; Rao, Vinay P.; Ricci, Davide; Miyagi, Naoto; Gazi, Mozammel; Whelan, Shelly; Edgerton, Sarah; Byrne, Guerard W.
- Abstract
The article outlines the study conducted on xenotransplantation using GT-KO pigs in the U.S. It reveals that one of the fundamental advantages of xenotransplantation is the donor organ, because it is derived from a pig which can be genetically modified to relieve the patient of immunosuppressive burden. The donor organs eliminated the need for systemic complement inhibition and reduced the immunosuppressive burden of the recipient.
- Subjects
UNITED States; TRANSPLANTATION of organs, tissues, etc.; SWINE; XENOGRAFTS; CELL transplantation
- Publication
Xenotransplantation, 2007, Vol 14, Issue 2, p181
- ISSN
0908-665X
- Publication type
Other
- DOI
10.1111/j.1399-3089.2007.00386_6.x