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- Title
Blood dendritic cells are decreased in acute graft-versus-host disease.
- Authors
Takiebayashi, M.; Amakawa, R.; Tajima, K.; Miyaji, M.; Nakamura, K.; Ito, T.; Matsumoto, N.; Miyazaki, Y.; Zen, K.; Kishimoto, Y.; Fukuhara, S.
- Abstract
The recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) often develop acute graft-versus-host disease (aGVHD), which is closely related to morbidity and mortality. However, the essential part of the immune responses elicited in aGVHD remains largely unknown. We attempt to determine if peripheral blood dendritic cells (PBDCs) are altered in aGVHD, and find that the number of PBDCs (both myeloid and lymphoid DCs) is significantly decreased. Immunohistochemical staining of the biopsied skin from patients with aGVHD demonstrates that a number of fascin + cells with dendritic projections infiltrate the dermis of the skin. Based on these findings, we hypothesize that the PBDCs are recruited to the affected tissues and may thus play important roles in immune responses elicited in aGVHD.
- Subjects
DENDRITIC cells; LYMPHOID tissue; HEMATOPOIETIC stem cells; BONE marrow cells; TRANSPLANTATION of organs, tissues, etc.; IMMUNOLOGY
- Publication
Bone Marrow Transplantation, 2004, Vol 33, Issue 10, p989
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1704406