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- Title
Quantitative, not qualitative, differences in CD8.
- Authors
Lyman, Michael A.; Myoung, Jinjong; Mohindru, Mani; Kim, Byung S.
- Abstract
Theiler's murine encephalomyelitis virus (TMEV) infection of the CNS induces an immune-mediated demyelinating disease in susceptible mouse strains and serves as a relevant infection model for human multiple sclerosis. However, it is not yet clear what immunological parameters determine the susceptibility of SJL/J mice compared to resistant mice. We have here compared the TMEV-specific CD8 T cell responses in highly susceptible SJL/J mice with those of highly resistant C57BL/6 mice. Our results clearly indicate that the levels of initial responses of infiltrating CD8 T cells to viral capsid proteins are higher in resistant C57BL/6 mice compared to susceptible SJL/J mice. However, the level of virus-specific CD8 T cells was much more rapidly reduced in resistant C57BL/6, resulting in a higher CD8 T cell level in SJL/J mice later in viral infection. The activation states, cytokine production, as well as the cytolytic function of the CD8 T cells were similar to each other in these mice. These results suggest that an initial induction of a vigorous CD8 T cell response to TMEV is critically important for the resistance to virally induced demyelinating disease.
- Publication
European Journal of Immunology, 2004, Vol 34, Issue 10, p2730
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200324811