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- Title
Hyperthermia with Chemotherapy for Unresectable Gastric Cancer in a Patient with a Vagus Nerve Stimulator Implant: A Case Report.
- Authors
Hirozumi Sawai; Shuhei Ueno; Yoshimi Yamaguchi; Yuka Suzuki; Akemi Murata; Enami Suganuma; Kazuya Yamamoto; Hiromasa Kuzuya; Shuji Koide; Masaaki Kurimoto; Takeshi Yanagi; Hajime Koide; Atsushi Kamiya
- Abstract
Objective: Unusual setting of medical care. Background: Radiofrequency (RF) hyperthermia is commonly used as an adjunct to established treatment modalities such as chemotherapy and radiotherapy for the management of cancer patients. This case report aims to introduce the use of hyperthermia, in combination with chemotherapy, for the treatment of unresectable gastric cancer in a patient implanted with a vagus nerve stimulator (VNS). Case Report: A 55-year-old man with dermatomyositis, laryngeal squamous cell carcinoma in situ and double synchronous gastric cancer was found to have unresectable gastric disease during surgery despite neoadjuvant chemotherapy. Postoperatively, he received chemotherapy with RF hyperthermia. The patient had a VNS implant to treat epileptic seizures. VNS failure due to RF hyperthermia was an area of significant concern, and the procedures were completed with a full preparation to manage epileptic seizures in the event of its anticipated occurrence. Twenty-one thermotherapies were performed over 21 weeks. After 3 courses of S-1 chemotherapy (12 weeks) with RF hyperthermia without any adverse events, the regimen was changed to S-1+ CDDP combination chemotherapy (SP) and RF hyperthermia. The patient continued to receive treatment with a decrease in the size of the primary gastric tumors as well as lymph node metastases, without major adverse events, until he died due to disseminated disease. Conclusions: We report the first case of unresectable gastric cancer with VNS implants in which chemo-hyperthermal therapy was safe and successful. This case report highlights the importance of providing a multidisciplinary treatment with appropriate measures for patients with intractable cancer who have received special treatments for underlying comorbidities.
- Subjects
VAGUS nerve; STOMACH cancer; SQUAMOUS cell carcinoma; FEVER; ANTINEOPLASTIC combined chemotherapy protocols; BOWEN'S disease; DERMATOMYOSITIS
- Publication
American Journal of Case Reports, 2021, Vol 22, p1
- ISSN
1941-5923
- Publication type
Article
- DOI
10.12659/AJCR.931564