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- Title
Extracellular Vesicles in Lung Cancer: Implementation in Diagnosis and Therapeutic Perspectives.
- Authors
Carreca, Anna Paola; Tinnirello, Rosaria; Miceli, Vitale; Galvano, Antonio; Gristina, Valerio; Incorvaia, Lorena; Pampalone, Mariangela; Taverna, Simona; Iannolo, Gioacchin
- Abstract
Simple Summary: Cell–cell communication mechanisms are gathering growing scientific interest, particularly in the context of cancer cells and the tumor microenvironment. Extracellular vesicles are gaining increased interest due to their relevance in tumor molecular characterization, classification, diagnosis, prognosis evaluation, and response to treatment. Many advances have been made in the clinical and therapeutic fields, exploiting increasingly precise biomolecular engineering strategies. This review aims to focus on the role of extracellular vesicles (EVs) as diagnostic and therapeutic tools in lung cancer. Lung cancer represents the leading cause of cancer-related mortality worldwide, with around 1.8 million deaths in 2020. For this reason, there is an enormous interest in finding early diagnostic tools and novel therapeutic approaches, one of which is extracellular vesicles (EVs). EVs are nanoscale membranous particles that can carry proteins, lipids, and nucleic acids (DNA and RNA), mediating various biological processes, especially in cell–cell communication. As such, they represent an interesting biomarker for diagnostic analysis that can be performed easily by liquid biopsy. Moreover, their growing dataset shows promising results as drug delivery cargo. The aim of our work is to summarize the recent advances in and possible implications of EVs for early diagnosis and innovative therapies for lung cancer.
- Subjects
TREATMENT of lung tumors; EXTRACELLULAR vesicles; PROTEINS; CELL communication; EARLY detection of cancer; LIPIDS; TUMOR markers; DNA; BODY fluid examination; RNA; CELL lines; LUNG tumors; NUCLEIC acids
- Publication
Cancers, 2024, Vol 16, Issue 11, p1967
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16111967