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- Title
The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas.
- Authors
Gatti, Veronica; Bernassola, Francesca; Talora, Claudio; Melino, Gerry; Peschiaroli, Angelo
- Abstract
The ubiquitin system is a dynamic regulatory pathway controlling the activity, subcellular localization and stability of a myriad of cellular proteins, which in turn affects cellular homeostasis through the regulation of a variety of signaling cascades. Aberrant activity of key components of the ubiquitin system has been functionally linked with numerous human diseases including the initiation and progression of human tumors. In this review, we will contextualize the importance of the two main components of the ubiquitin system, the E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), in the etiology of squamous cell carcinomas (SCCs). We will discuss the signaling pathways regulated by these enzymes, emphasizing the genetic and molecular determinants underlying their deregulation in SCCs.
- Subjects
PROTEIN metabolism; CELLULAR signal transduction; ENZYMES; HOMEOSTASIS; METABOLISM; ONCOGENES; SQUAMOUS cell carcinoma
- Publication
Cancers, 2020, Vol 12, Issue 6, p1595
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers12061595