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- Title
Satietogenic Protein from Tamarind Seeds Decreases Food Intake, Leptin Plasma and CCK-1r Gene Expression in Obese Wistar Rats.
- Authors
Costa, Izael S.; Medeiros, Amanda F.; Carvalho, Fabiana M.C.; Lima, Vanessa C.O.; Serquiz, Raphael P.; Serquiz, Alexandre C.; Silbiger, Vivian N.; Bortolin, Raul H.; Maciel, Bruna L.L.; Santos, Elizeu A.; Morais, Ana H.A.
- Abstract
Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats. Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Lean animals were fed the standard diet for the 10 days. Food intake, zoometric measurements, plasma CCK, plasma leptin, relative mRNA expression of intestinal CCK-related genes, and expression of the ob gene in subcutaneous adipose tissue were assessed. Results: TTI decreased food intake but did not increase plasma CCK in obese animals. On the other hand, TTI treatment decreased CCK-1R gene expression in obese animals compared with the obese group with no treatment (p = 0.027). Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals. Conclusion: We suggest that TTI by decreasing plasma leptin may improve CCK action, regardless of its increase in plasma from obese rats, since food intake was lowest.
- Subjects
LABORATORY rats; OBESITY; CHOLECYSTOKININ; PROTEINS; TRYPSIN inhibitors; GENE expression; INGESTION
- Publication
Obesity Facts: The European Journal of Obesity, 2018, Vol 11, Issue 6, p440
- ISSN
1662-4025
- Publication type
Article
- DOI
10.1159/000492733