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- Title
The antimicrobial effects of selenium nanoparticle-enriched probiotics and their fermented broth against Candida albicans.
- Authors
Kheradmand, Erfan; Rafii, Fatemeh; Yazdi, Mohammad Hossien; Sepahi, Abas Akhavan; Shahverdi, Ahmad Reza; Oveisi, Mohammad Reza
- Abstract
Background: Lactic acid bacteria are considered important probiotics for prevention of some infections. The aim of this work was to investigate the effect of selenium dioxide on the antifungal activity of actobacillus plantarum and L. johnsonii against Candida albicans. Methods: Lactobacillus plantarum and L. johnsonii cells, grown in the presence and absence of selenium dioxide, and their cell-free spent culture media were tested for antifungal activity against C. albicans ATCC 14053 by a hole-plate diffusion method and a time-kill assay. Results: Both L. plantarum and L. johnsonii reduced selenium dioxide to cell-associated elemental selenium nanoparticles. The cell-free spent culture media, from both Lactobacillus species that had been grown with selenium dioxide for 48 h, showed enhanced antifungal activity against C. albicans. Enhanced antifungal activity of cell biomass against C. albicans was also observed in cultures grown with selenium dioxide. Conclusions: Selenium dioxide-treated Lactobacillus spp. or their cell-free spent broth inhibited the growth of C. albicans and should be investigated for possible use in anti-Candida probiotic formulations in future.
- Subjects
ANTI-infective agents; CANDIDA albicans; FERMENTATION; FOOD; LACTOBACILLUS; NANOPARTICLES; RESEARCH funding; SELENIUM; PROBIOTICS
- Publication
DARU: Journal of Pharmaceutical Sciences, 2014, Vol 22, p1
- ISSN
1560-8115
- Publication type
Article
- DOI
10.1186/2008-2231-22-48