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- Title
High Serum Levels of CD14 in Patients with Allergic Rhinitis.
- Authors
Mohammadi, Mojgan; Marzouni, Hadi Zare; Azad, Farahzad Jabbari; Hosseini, Reza Farid; Khoshkhoi, Maryam; Tavakolafshari, Jalil
- Abstract
Objective: Allergic Rhinitis (AR) is the most common type of chronic rhinitis. It is affecting 10 to 20% of the population. The prevalence of AR has increased worldwide. There are many allergic and inflammatory mediators involved in the immunopathogenesis of AR. Soluble CD14 can be produced by LPS-stimulated antigen presenting cells in the immune system. Previous studies showed that the ratio of Th1 to Th2 and IgE can be affected by CD14 expression. Therefore, the aim of this study was investigated the correlation between the serum levels of CD14 and allergic rhinitis. Material and Methods: 50 patients with AR and 50 healthy controls were enrolled in this study. The samples were collected randomly and the range of age was between 18 to 60 years. The serum level of CD14 was measured by enzyme-linked immunosorbent assay (ELISA). Data was analyzed by spss16 software. Results: The mean age of case and control groups was 32.54 ± 9.31 and 31.01 ± 8.01, respectively. The serum levels of CD14 was significantly higher in the case group when comparing with the control group (p <0.007). Conclusion: Based on the results of this study, CD14 in the serum of patients with AR might be an important immune biomarker for the disorder. We suggest increasing the sample size to get better conclusion.
- Subjects
RHINITIS; IMMUNOTHERAPY
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p97
- ISSN
1735-1502
- Publication type
Abstract