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- Title
Association of Long Non-Coding RNA MEG3 Polymorphisms and Risk of Prostate Cancer in Chinese Han Population.
- Authors
Bin Xu; Minhao Zhang; Chunhui Liu; Can Wang; Zonghao You; Yali Wang; Ming Chen; Xu, Bin; Zhang, Minhao; Liu, Chunhui; Wang, Can; You, Zonghao; Wang, Yali; Chen, Ming
- Abstract
<bold>Purpose: </bold>To explore the association between MEG3 polymorphisms and the risk of prostate cancer in the Chinese Han population.<bold>Materials and Methods: </bold>Two MEG3 single-nucleotide polymorphisms (SNPs) (rs11627993 C >T rs7158663 A>G) were genotyped in a case-control study in which 165 prostate cancer patients and 200 healthy controls were recruited by a Real-Time Polymerase Chain Reaction (PCR) with the TaqMan assay. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of association.<bold>Results: </bold>No statistically significant differences were found in the allele or genotype distributions of the MEG3 rs11627993 C >T and rs7158663 A > G polymorphisms among cases or healthy control subjects (rs11627993: CC vs CA: 95% CI = 0.54-1.95, ORs = 1.03; CC vs AA: 95% CI = 0.67-2.54, ORs = 1.30 ; CC/CA vs AA: 95% CI = 0.81-1.98, ORs = 1.26 , P = .29 ; C vs A: 95% CI = 0.85-1.57, ORs = 1.16, P = .35; rs7158663: AA vs AG: 95% CI = 0.76-5.08, ORs = 1.97, AA vs GG: 95% CI = 0.57-3.29, ORs = 1.37; AA/AG vs GG : 95% CI = 0.56-1.32, ORs = 0.86, P = .49; A vs G: 95% CI = 0.69-1.39, ORs = 0.98, P = .91) Further stratified analysis detected no significant association.<bold>Conclusion: </bold>The MEG3 polymorphisms (rs11627993 C>T and rs7158663 A>G) does not influence the susceptibility to prostate cancer.
- Subjects
CHINESE people; LINCRNA; PROSTATE cancer; PROSTATE cancer patients; SINGLE nucleotide polymorphisms
- Publication
Urology Journal, 2021, Vol 18, Issue 2, p176
- ISSN
1735-1308
- Publication type
journal article
- DOI
10.22037/uj.v16i7.5585