We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Trilostane Therapy for Treatment of Pituitary-Dependent Hyperadrenocorticism in 5 Cats.
- Authors
Neiger, Reto; Witt, Angela L.; Noble, Ann; German, Alexander J.
- Abstract
Hyperadrenocorticism is a rare syndrome in cats. Current medical therapy is unsatisfactory and prognosis for long-term survival with surgical treatment is guarded. We report on 5 cats treated with the 3-beta hydroxysteroid dehydrogenase inhibitor trilostane. Diagnosis was confirmed in all cats by endocrine testing. Three cats had concurrent diabetes mellitus. Trilostane reduced clinical signs and improved endocrine test results in all cats, but insulin requirements did not change and all continued to have some signs of hypercortisolemia. Two died or were euthanized after 16 and 140 days, whereas 3 were still alive 6, 11, and 20 months after the start of trilostane therapy. Trilostane ameliorates clinical signs of feline hyperadrenocorticism, but more research is needed before it can be recommended for treatment.
- Publication
Journal of Veterinary Internal Medicine, 2004, Vol 18, Issue 2, p160
- ISSN
0891-6640
- Publication type
Article
- DOI
10.1111/j.1939-1676.2004.tb00156.x