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- Title
Higher Serum Urate Levels Are Associated With an Increased Risk for Sudden Cardiac Death.
- Authors
Colantonio, Lisandro D.; Reynolds, Richard J.; Merriman, Tony R.; Gaffo, Angelo; Singh, Jasvinder A.; Plante, Timothy B.; Chaudhary, Ninad S.; Armstrong, Nicole D.; Soliman, Elsayed Z.; Curtis, Jeffrey R.; Bridges Jr., S. Louis; Lang, Leslie; Howard, George; Safford, Monika M.; Saag, Kenneth G.; Muntner, Paul; Irvin, Marguerite Ryan
- Abstract
Objective: To determine the association of serum urate (SU) levels with sudden cardiac death and incident coronary heart disease (CHD), separately, among adults without a history of CHD. Methods: We conducted a case-cohort analysis of Black and White participants aged ≥ 45 years enrolled in the REason for Geographic And Racial Differences in Stroke (REGARDS) study without a history of CHD at baseline between 2003 and 2007. Participants were followed for sudden cardiac death or incident CHD (i.e., myocardial infarction [MI] or death from CHD excluding sudden cardiac death) through December 31, 2013. Baseline SU was measured in a random sample of participants (n = 840) and among participants who experienced sudden cardiac death (n = 235) or incident CHD (n = 851) during follow-up. Results: Participants with higher SU levels were older and more likely to be male or Black. The crude HR (95% CI) per 1 mg/dL higher SU level was 1.26 (1.14-1.40) for sudden cardiac death and 1.17 (1.09-1.26) for incident CHD. After adjustment for age, sex, race, and cardiovascular risk factors, the HR (95% CI) per 1 mg/dL higher SU level was 1.19 (1.03-1.37) for sudden cardiac death and 1.05 (0.96-1.15) for incident CHD. HRs for sudden cardiac death were numerically higher among participants aged 45-64 vs ≥ 65 years, without vs with diabetes, and among those of White vs Black race, although P values for effect modification were all ≥ 0.05. Conclusion: Higher SU levels were associated with an increased risk for sudden cardiac death but not with incident CHD.
- Subjects
CORONARY disease; DISEASE incidence; CARDIAC arrest; RESEARCH funding; URIC acid
- Publication
Journal of Rheumatology, 2021, Vol 48, Issue 11, p1745
- ISSN
0315-162X
- Publication type
Article
- DOI
10.3899/jrheum.210139