We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis.
- Authors
Adya, Raghu; Tan, Bee K.; Punn, Anu; Chen, Jing; Randeva, Harpal S.
- Abstract
Aims: Visfatin is a novel adipokine whose plasma concentrations are altered in obesity and obesity-related disorders; these states are associated with an increased incidence of cardiovascular disease. We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades.
- Subjects
VASCULAR endothelial growth factors; GROWTH factors; MITOGEN-activated protein kinases; PROTEIN kinases; NEOVASCULARIZATION
- Publication
Cardiovascular Research, 2008, Vol 78, Issue 2, p356
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvm111