We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors
- Authors
Chi, Neil C.; Karliner, Joel S.
- Abstract
During the past several years much new evidence has accumulated regarding the molecular and biochemical mechanisms underlying cardiac responses to hypoxia and to ischemia/reperfusion injury. Studies have involved cell culture, and ex vivo and in vivo preparations. This review focuses on regulation of two transcription factors that are thought to be important in these processes, hypoxia-inducible factor1α (HIF-1α) and heat shock factor (HSF). Both of these molecules are expressed acutely and chronically in response to hypoxia and ischemia/reperfusion, and both have numerous targets that comprise part of integrated response to ischemic injury aimed at promoting cell survival. Emphasis is placed on new mechanisms of action that regulate HIF-1α, HSF, and heat shock proteins as key responses to hypoxia and ischemia, and possible approaches to therapy based on these data are discussed.
- Subjects
CORONARY disease; REPERFUSION injury; HYPOXEMIA; TRANSCRIPTION factors
- Publication
Cardiovascular Research, 2004, Vol 61, Issue 3, p437
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1016/j.cardiores.2003.11.033