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- Title
Corticolimbic anatomical characteristics predetermine risk for chronic pain.
- Authors
Vachon-Presseau, Etienne; Tétreault, Pascal; Petre, Bogdan; Huang, Lejian; Berger, Sara E.; Torbey, Souraya; Baria, Alexis T.; Mansour, Ali R.; Hashmi, Javeria A.; Griffith, James W.; Comasco, Erika; Schnitzer, Thomas J.; Baliki, Marwan N.; Apkarian, A. Vania
- Abstract
SEE TRACEY DOI101093/BRAIN/AWW147 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Mechanisms of chronic pain remain poorly understood. We tracked brain properties in subacute back pain patients longitudinally for 3 years as they either recovered from or transitioned to chronic pain. Whole-brain comparisons indicated corticolimbic, but not pain-related circuitry, white matter connections predisposed patients to chronic pain. Intra-corticolimbic white matter connectivity analysis identified three segregated communities: dorsal medial prefrontal cortex-amygdala-accumbens, ventral medial prefrontal cortex-amygdala, and orbitofrontal cortex-amygdala-hippocampus. Higher incidence of white matter and functional connections within the dorsal medial prefrontal cortex-amygdala-accumbens circuit, as well as smaller amygdala volume, represented independent risk factors, together accounting for 60% of the variance for pain persistence. Opioid gene polymorphisms and negative mood contributed indirectly through corticolimbic anatomical factors, to risk for chronic pain. Our results imply that persistence of chronic pain is predetermined by corticolimbic neuroanatomical factors.
- Subjects
BRAIN anatomy; CHRONIC pain; BACKACHE; NEURAL circuitry; WHITE matter (Nerve tissue); AMYGDALOID body; PAIN risk factors; BASAL ganglia; BRAIN; FRONTAL lobe; HIPPOCAMPUS (Brain); LONGITUDINAL method; MAGNETIC resonance imaging; NERVOUS system; NEUROLOGIC examination; RESEARCH funding
- Publication
Brain: A Journal of Neurology, 2016, Vol 139, Issue 7, p1958
- ISSN
0006-8950
- Publication type
journal article
- DOI
10.1093/brain/aww100