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- Title
When the Circadian Clock Meets the Melanin Pigmentary System.
- Authors
Slominski, Andrzej T; Hardeland, Rüdiger; Reiter, Russel J
- Abstract
Silencing of BMAL1 and PER1 stimulates melanogenic activity of follicular and epidermal melanocytes, indicating a novel role for peripheral circadian clock processes in the regulation of melanin pigmentation. Linking the expression levels of BMAL1/PER1 with changes in melanogenesis opens exciting opportunities to study the role of the local molecular clock in modulation of melanocyte functions in the hair follicle and the epidermis with attendant effects on epidermal barrier functions in general.
- Subjects
CIRCADIAN rhythms; MOLECULAR clock; MELANINS; ARYL hydrocarbon receptors; MELANOCYTES; GENE expression
- Publication
Journal of Investigative Dermatology, 2015, Vol 135, Issue 4, p943
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2014.553