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- Title
Algorithm for betalactam allergy diagnosis.
- Authors
Doña, Inmaculada; Romano, Antonino; Torres, María José
- Abstract
The diagnostic approach in suspected hypersensitivity reactions to betalactams (BL) involves a detailed clinical history, followed by in vitro testing, skin tests (ST), and drug provocation tests (DPT) (Figure). For IR, it is advisable to perform in vitro tests in addition to ST in high-risk patients in order to improve the sensitivity of the allergy workup and thus reduce the use of DPT. For NIR, in vitro tests include the lymphocyte transformation test and enzyme-linked immunosorbent spot assay; however, they are not routinely used and thus have not been validated in large patient cohorts.[3].
- Subjects
TOXIC epidermal necrolysis; DRESS syndrome; ALLERGIES
- Publication
Allergy, 2019, Vol 74, Issue 9, p1817
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.13844