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- Title
Magnesium Sulfate Reduces Carrageenan-Induced Rat Paw Inflammatory Edema Via Nitric Oxide Production.
- Authors
Srebro, Dragana; Dožić, Branko; Savić Vujović, Katarina; Medić Brkić, Branislava; Vučković, Sonja
- Abstract
Background: Magnesium is an antagonist of the N-methyl-D-aspartate receptor. This study aimed to investigate the anti-edematous effect of magnesium sulfate (MS) in different protocols of use and the possible mechanism of its action. Methods: In a rat model of carrageenan-induced paw inflammation, the anti-edematous activity of MS was assessed with a plethysmometer. The effects of the nonselective inhibitor (L-NAME), selective inhibitor of neuronal (L-NPA) and inducible (SMT) nitric oxide synthase on the effects of MS were evaluated. Results: MS administered systemically before or after inflammation reduced edema by 30% (5 mg/kg, P <.05) and 55% (30 mg/kg, P <.05). MS administered locally (.5 mg/paw, P <.05) significantly prevented the development of inflammatory edema by 60%. L-NAME, intraperitoneally administered before MS, potentiated (5 mg/kg, P <.05) or reduced (3 mg/kg, P <.05), while in the highest tested dose L-NPA (2 mg/kg, P <.01) and SMT (.015 mg/kg, P <.01) reduced the anti-edematous effect of MS. Conclusions: Magnesium is a more effective anti-edematous drug in therapy than for preventing inflammatory edema. The effect of MS is achieved after systemic and local peripheral administration and when MS is administered as a single drug in a single dose. This effect is mediated at least in part via the production of nitric oxide.
- Subjects
MAGNESIUM sulfate; NITRIC oxide; NITRIC-oxide synthases; CARRAGEENANS; METHYL aspartate receptors; FOOT; EDEMA
- Publication
Dose-Response, 2023, Vol 21, Issue 1, p1
- ISSN
1559-3258
- Publication type
Article
- DOI
10.1177/15593258231155788