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- Title
Chronic fatigue syndrome is associated with oxidative stress induced by in vivo infusion of hydrogen peroxide in pig.
- Authors
Lackeyram, Dale; Young, Denise; Archbold, Tania; Shoveller, Anna-Kate; Chengbo Yang; Widowski, Tina; Mine, Yoshinori; Fan, Ming Z.
- Abstract
Chronic fatigue syndrome (CFS) is characterized by persistent and relapsing fatigue that involves oxidative stress in its pathogenesis. In this study we report on the prevalence of CFS-associated symptoms in an oxidative stress pig model. Piglets of 5 d of age were fitted with an intraperitoneal catheter and infused with either H202 at 5 mmol/kg BW (PER, n=8) or the same volume of saline (CON, n=8) in six 20-ml doses daily for a period of 10 d. During this time, animal behavior was monitored and blood samples taken. At the end of the study, CON piglets had higher (P<0.05) BW gain in comparison to the PER group (CON, 111.46±9.00 vs. PER, 74.78±9.62 g/d). Since there were no differences (P>0.05) in the formula intake between PER and CON groups, the CON piglets had lower (P<0.05) feed to gain ratios in comparison to the PER piglets (CON, 8.72±0.85 vs. PER, 15.82±0.83 ml/g). Plasma GSH levels remained similar (P>0.05) to the pre-infusion level over the study duration in the CON group, whereas this was 65% lower (P<0.05) than the pre-infusion level in the PER' group. Additionally, the PER treatment piglets were more lethargic, less mobile and less responsive to new environmental stimuli. These piglets (PER group) also consumed their meals at a slower pace and all developed diarrhea in comparison to the CON group. We conclude that chronic fatigue syndrome could be established by infusion of a suitable dose of hydrogen peroxide to investigate mechanisms and modulations of CFS in association with oxidative stress in the pig. Supported by OMAFRA of Canada.
- Subjects
CHRONIC fatigue syndrome; OXIDATIVE stress; HYDROGEN peroxide; SWINE; CHRONIC diseases
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA377
- ISSN
0892-6638
- Publication type
Article