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- Title
Practical synthesis of polysubstituted naphthalene derivatives via HNTf<sub>2</sub>-catalyzed benzannulation reaction.
- Authors
Ponra, Sudipta; Vitale, Maxime R.; Michelet, Véronique; Ratovelomanana-Vidal, Virginie
- Abstract
The synthesis of polysubstituted naphthalenes using the triflimide-catalyzed benzannulation of arylacetaldehydes with alkynes at room temperature is described. This method demonstrates a high functional group tolerance and, in the case of halogen substituted naphthalenes, opens the route for further functionalization by palladium-catalyzed cross-coupling reactions. With an analogous organocatalytic strategy, arylepoxides or 2-arylacetal derivatives are also suitable partners in the related benzannulation reactions with aryl-alkynes.
- Subjects
NAPHTHALENE derivatives; ANNULATION; CYCLOHEXANONES; CATALYSIS; SUBSTITUTION reactions; CHEMICAL synthesis
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2016, p62
- ISSN
1551-7004
- Publication type
Article
- DOI
10.3998/ark.5550190.p009.219