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- Title
DEPENDENCE OF THE BYSTANDER EFFECT FOR MICRONUCLEUS FORMATION ON DOSE OF HEAVY-ION RADIATION IN NORMAL HUMAN FIBROBLASTS.
- Authors
Yoshitaka Matsumoto; Nobuyuki Hamada; Mizuho Aoki-Nakano; Tomoo Funayama; Tetsuya Sakashita; Seiichi Wada; Takehiko Kakizaki; Yasuhiko Kobayashi; Yoshiya Furusawa
- Abstract
Ionising radiation-induced bystander effects are well recognised, but its dependence on dose or linear energy transfer (LET) is still a matter of debate. To test this, 49 sites in confluent cultures of AG01522D normal human fibroblasts were targeted with microbeams of carbon (103 keV μm-1), neon (375 keV μm-1) and argon ions (1260 keV μm-1) and evaluated for the bystander- induced formation of micronucleus that is a kind of a chromosome aberration. Targeted exposure to neon and argon ions significantly increased the micronucleus frequency in bystander cells to the similar extent irrespective of the particle numbers per site of 1-6. In contrast, the bystander micronucleus frequency increased with increasing the number of carbon-ion particles in a range between 1 and 3 particles per site and was similar in a range between 3 and 8 particles per site. These results suggest that the bystander effect of heavy ions for micronucleus formation depends on dose.
- Subjects
RADIOBIOLOGY; NUCLEOLUS; FIBROBLASTS; LINEAR energy transfer; CHROMOSOME abnormalities; HEAVY ions
- Publication
Radiation Protection Dosimetry, 2015, Vol 166, Issue 1-4, p152
- ISSN
0144-8420
- Publication type
Article
- DOI
10.1093/rpd/ncv177