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- Title
An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage.
- Authors
van Lieshout, Jasper H.; Dibué-Adjei, Maxine; Cornelius, Jan F.; Slotty, Philipp J.; Schneider, Toni; Restin, Tanja; Boogaarts, Hieronymus D.; Steiger, Hans-Jakob; Petridis, Athanasios K.; Kamp, Marcel A.
- Abstract
Pathophysiological processes following subarachnoid hemorrhage (SAH) present survivors of the initial bleeding with a high risk of morbidity and mortality during the course of the disease. As angiographic vasospasm is strongly associated with delayed cerebral ischemia (DCI) and clinical outcome, clinical trials in the last few decades focused on prevention of these angiographic spasms. Despite all efforts, no new pharmacological agents have shown to improve patient outcome. As such, it has become clear that our understanding of the pathophysiology of SAH is incomplete and we need to reevaluate our concepts on the complex pathophysiological process following SAH. Angiographic vasospasm is probably important. However, a unifying theory for the pathophysiological changes following SAH has yet not been described. Some of these changes may be causally connected or present themselves as an epiphenomenon of an associated process. A causal connection between DCI and early brain injury (EBI) would mean that future therapies should address EBI more specifically. If the mechanisms following SAH display no causal pathophysiological connection but are rather evoked by the subarachnoid blood and its degradation production, multiple treatment strategies addressing the different pathophysiological mechanisms are required. The discrepancy between experimental and clinical SAH could be one reason for unsuccessful translational results.
- Subjects
SUBARACHNOID hemorrhage; CEREBRAL ischemia; CEREBRAL vasospasm; PATHOLOGICAL physiology; CLINICAL trials
- Publication
Neurosurgical Review, 2018, Vol 41, Issue 4, p917
- ISSN
0344-5607
- Publication type
Article
- DOI
10.1007/s10143-017-0827-y