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- Title
BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells
- Authors
Politis, Panagiotis K.; Akrivou, Sofia; Hurel, Catherine; Papadodima, Olga; Matsas, Rebecca
- Abstract
Abstract: Histone deacetylase inhibitors arrest the growth of neuroblastoma cells and induce differentiation. Identification of target genes that co-ordinate and mediate these effects is important for understanding the function of this novel class of antitumour drugs. We report here that trichostatin-A (TSA) specifically induces the transcription of Cend1, a neuronal-lineage specific regulator of cell cycle exit and differentiation, in neuroblastoma Neuro2A cells, but not in non-neuronal cells. Furthermore, we show that knockdown of Cend1 alleviates both the anti-proliferative and differentiation effect of TSA. Our findings suggest that Cend1 is an important molecular target for HDAC inhibition.
- Subjects
HISTONE deacetylase; NEUROBLASTOMA; HEREDITY; TUMORS
- Publication
FEBS Letters, 2008, Vol 582, Issue 5, p741
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.01.052