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- Title
Treatment-associated severe thrombocytopenia affects survival rate in esophageal cancer patients undergoing concurrent chemoradiotherapy.
- Authors
Huang, Y. M.; Wang, C. H.; Huang, J. S.; Tsai, C. S.; Yeh, K. Y.; Lan, Y. J.; Wu, T. H.; Chang, P. H.; Chang, Y. S.; Lai, C. H.
- Abstract
<bold>Background: </bold>Esophageal cancer is commonly treated with surgery, concurrent chemoradiotherapy (CCRT), or a combination of both. The correlation between the hematological parameters during CCRT and early survival of esophageal cancer has not been fully evaluated.<bold>Materials and Methods: </bold>We analyzed the records of 65 esophageal cancer patients treated by CCRT between 2007 and 2010 retrospectively. The association between CCRT-associated myelosuppression, demographic variables, and survival rates were analyzed by univariate and multivariate analysis.<bold>Results: </bold>The univariate analysis showed that tumor extent of T3-4, a higher stage of tumor, a lower albumin level, grade 3 or higher anemia and thrombocytopenia, and interruptions in treatment affected survival rates. Further, the multivariate analysis revealed that stage IV (P = 0.030) is an independently negative prognostic factor for a one-year survival rate. Stage IV (P = 0.035), tumor extent of T3-4 (P = 0.002), and grade 3-4 thrombocytopenia (P = 0.015) are independently negative prognostic factors for a two-year survival rate.<bold>Conclusions: </bold>Severe decrease in platelet count during CCRT independently affects survival of esophageal cancer patients in addition to stage of the tumor.
- Subjects
ESOPHAGEAL cancer; CHEMORADIOTHERAPY; ALBUMINS; STATISTICAL correlation; MYELOSUPPRESSION; UNIVARIATE analysis
- Publication
Indian Journal of Cancer, 2015, Vol 52, Issue 3, p454
- ISSN
0019-509X
- Publication type
journal article
- DOI
10.4103/0019-509X.176708